DEVELOPMENT OF A HIGH-THROUGHPUT SCREEN TO IDENTIFY SMALL MOLECULE ENHANCERS OF SARCOSPAN FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY

Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy

Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix.Transgenic overexpression of the transmembrane protein sarcospan (SSPN) in the DMD mdx mouse model significantly reduces disease pathology by restoring membrane adhesion.Identifying SSPN-based therapies has the potential to b

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Remote onboarding and training of new program coordinators into the medical education office during Covid-19 social distance quarantine: process and recommendations

Background The Medical Education Office at Rochester Regional Health was required to remotely onboard and train its new program coordinators using telework during the Covid-19 quarantine restrictions mandating all non-clinical administrative TROUSERS SPLIT SUIT AUDEN staff work from home.Objective To implement a remote onboarding and training proce

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